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Anastrozole, Letrozole, or Exemestane? A Clear-Eyed Patient's Guide to the Three Aromatase Inhibitors

If your oncologist has recommended an aromatase inhibitor for hormone receptor-positive breast cancer, you may wonder why one medication was chosen over another. Anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) each have distinct pharmacological profiles, side effect patterns, and cost considerations. This guide helps you understand the key differences so you can have a more informed conversation with your care team.